![]() This increased cardiovascular risk is attributed to a reduction in oxygen levels, which activate the sympathetic nervous system and lead to elevated oxidative stress and inflammation. If left untreated, patients with SDB face a substantially heightened susceptibility to encountering complications related to the heart and cerebrovascular system, as well as increased mortality from all causes. Multiple studies have provided compelling evidence that there exists a robust association between SDB and the development of cardiovascular disease. ![]() Unfortunately, SDB is often undiagnosed in clinical settings. The prevalence of SDB is expected to increase in the future because of the increasing prevalence of obesity and aging. It is worth noting that among different countries, China holds the distinction of having the highest prevalence rate of SDB. Notably, recent investigations indicate that approximately 936 million adults are affected by SDB. These episodes can result in a lack of oxygen during sleep. It is characterized by the frequent occurrence of episodes involving apnea, which is the temporary cessation of breathing, and hypopnea, which is decreased airflow. Sleep-disordered breathing (SDB) is a prevalent condition affecting many individuals worldwide. This finding emphasizes the importance of close monitoring for dyslipidemia, which is considered an early indicator of atherosclerosis in patients with SDB who experience nocturnal hypoxia. This study revealed that higher meanSpO2 is significantly and negatively associated with hyperlipidemia in adult community residents with SDB, particularly when the meanSpO2 exceeds 95. When meanSpO2 ≥ 95%, a difference of 1 in the meanSpO2 corresponded to a 0.07 difference in the risk of hyperlipidemia. The inflection points were determined to be 95. ![]() Upon conducting a nonlinearity test, the relationship between the meanSpO2 and hyperlipidemia was nonlinear. In the fully adjusted model, the meanSpO2 was negatively associated with hyperlipidemia (0.9303 ). ![]() Of the total sample size, 55.7% were male. The average age of the participants was 56.15 ± 13.11 years. The age of the individuals involved in the study spanned from 20 to 90 years. Subgroup analyses were conducted to stratify data according to age, sex, waist circumference, and chronic diseases. To understand the association between dyslipidemia and hypoxemia parameters, a multivariable logistic regression model was used. Type IV sleep monitoring was employed to measure hypoxemia parameters, and lipoproteins were evaluated using fasting blood samples. This cross-sectional study collected data from The Guangdong Sleep Health Study, which included 3829 participants. Additionally, this study aimed to identify the nocturnal hypoxia parameters having the strongest correlation with this relationship. Therefore, the primary objective of this research endeavor is to scrutinize the correlation between nocturnal hypoxemia and blood lipid concentrations among adult individuals residing in the community who exhibit symptoms of SDB. This discrepancy in findings may be because studies that primarily focused on hospital-based populations may not be applicable to community-based populations. Currently, there is limited and controversial clinical research on the correlation between sleep-disordered breathing (SDB) and dyslipidemia.
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